MYC overrides HIF-1α to regulate proliferating primary cell metabolism in hypoxia

MYC overrides HIF-1α to regulate proliferating primary cell metabolism in hypoxia

Hypoxia requires metabolic adaptations to sustain energetically demanding cellular activities. While the metabolic consequences of hypoxia have been studied extensively in cancer cell models, comparatively little is known about how primary cell metabolism responds to hypoxia. Thus, we developed meta...

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Bibliographic Details
Main Authors: Courtney A Copeland, Benjamin A Olenchock, David Ziehr, Sarah McGarrity, Kevin Leahy, Jamey D Young, Joseph Loscalzo, William M Oldham
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-07-01
Series:eLife
Subjects:
hypoxia
metabolic flux analysis
hypoxia-inducible factor
prolyl hydroxylase
MYC
Online Access:https://elifesciences.org/articles/82597

Internet

https://elifesciences.org/articles/82597

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