Drug characteristics derived from kinetic modeling: combined 11C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A

Drug characteristics derived from kinetic modeling: combined 11C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A

Abstract Background Antiepileptic drugs, levetiracetam (LEV) and brivaracetam (BRV), bind to synaptic vesicle glycoprotein 2A (SV2A). In their anti-seizure activity, speed of brain entry may be an important factor. BRV showed faster entry into the human and non-human primate brain, based on more rap...

Full description

Bibliographic Details
Main Authors: Mika Naganawa, Jean-Dominique Gallezot, Sjoerd J. Finnema, Ralph Paul Maguire, Joël Mercier, Nabeel B. Nabulsi, Sophie Kervyn, Shannan Henry, Jean-Marie Nicolas, Yiyun Huang, Ming-Kai Chen, Jonas Hannestad, Henrik Klitgaard, Armel Stockis, Richard E. Carson
Format: Article
Language:English
Published: SpringerOpen 2022-11-01
Series:EJNMMI Research
Subjects:
Positron emission tomography
Kinetic modeling
SV2A
Occupancy
Displacement
Online Access:https://doi.org/10.1186/s13550-022-00944-5

Internet

https://doi.org/10.1186/s13550-022-00944-5

Similar Items