The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival

The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival

Abstract Pigment cells and neuronal cells both are derived from the neural crest. Here, we describe the Pit‐Oct‐Unc (POU) domain transcription factor Brn3a, normally involved in neuronal development, to be frequently expressed in melanoma, but not in melanocytes and nevi. RNAi‐mediated silencing of...

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Dettagli Bibliografici
Autori principali: Tobias Hohenauer, Carola Berking, Andreas Schmidt, Sebastian Haferkamp, Daniela Senft, Claudia Kammerbauer, Sabine Fraschka, Saskia Anna Graf, Martin Irmler, Johannes Beckers, Michael Flaig, Achim Aigner, Sabrina Höbel, Franziska Hoffmann, Heiko Hermeking, Simon Rothenfusser, Stefan Endres, Thomas Ruzicka, Robert Besch
Natura: Articolo
Lingua:English
Pubblicazione: Springer Nature 2013-05-01
Serie:EMBO Molecular Medicine
Soggetti:
apoptosis
DNA damage
melanoma
neural crest factors
tumourigenesis
Accesso online:https://doi.org/10.1002/emmm.201201862

Accesso online

https://doi.org/10.1002/emmm.201201862

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