Genetic Ablation and Pharmacological Blockade of Bradykinin B1 Receptor Unveiled a Detrimental Role for the Kinin System in Chagas Disease Cardiomyopathy

Genetic Ablation and Pharmacological Blockade of Bradykinin B1 Receptor Unveiled a Detrimental Role for the Kinin System in Chagas Disease Cardiomyopathy

Chagas disease, the parasitic infection caused by <i>Trypanosoma cruzi</i>, afflicts about 6 million people in Latin America. Here, we investigated the hypothesis that <i>T. cruzi</i> may fuel heart parasitism by activating B1R, a G protein-coupled (brady) kinin receptor whos...

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Bibliographic Details
Main Authors: Ana Carolina Oliveira, Amanda Roberta Revoredo Vicentino, Daniele Andrade, Isabela Resende Pereira, Leonardo Saboia-Vahia, Otacílio da Cruz Moreira, Carla Eponina Carvalho-Pinto, Julia Barbalho da Mota, Leonardo Maciel, Glaucia Vilar-Pereira, João B. Pesquero, Joseli Lannes-Vieira, Pierre Sirois, Antônio Carlos Campos de Carvalho, Julio Scharfstein
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Journal of Clinical Medicine
Subjects:
bradykinin
Chagas disease
GPCRs
kallikrein
<i>Trypanosoma cruzi</i>
Online Access:https://www.mdpi.com/2077-0383/12/8/2888

Internet

https://www.mdpi.com/2077-0383/12/8/2888

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