The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity

The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity

A wide variety of oligomeric structures are formed during the aggregation of proteins associated with neurodegenerative diseases. Such soluble oligomers are believed to be key toxic species in the related disorders; therefore, identification of the structural determinants of toxicity is of upmost im...

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Bibliographic Details
Main Authors: Catherine K. Xu, Marta Castellana-Cruz, Serene W. Chen, Zhen Du, Georg Meisl, Aviad Levin, Benedetta Mannini, Laura S. Itzhaki, Tuomas P. J. Knowles, Christopher M. Dobson, Nunilo Cremades, Janet R. Kumita
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molecules
Subjects:
α-synuclein
toxic oligomers
Parkinson’s disease
familial mutations
α-helical structure
Online Access:https://www.mdpi.com/1420-3049/27/4/1293

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https://www.mdpi.com/1420-3049/27/4/1293

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