Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes

Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes

Monocytes constitutively adhere and crawl along the glomerular endothelium and are thought to contribute to glomerulonephritis. Here the authors use multiphoton microscopy to show local antigen presentation by MHCII+ monocytes to T cells in glomerular capillaries of mice.

Bibliographic Details
Main Authors: Clare L. V. Westhorpe, M. Ursula Norman, Pam Hall, Sarah L. Snelgrove, Michaela Finsterbusch, Anqi Li, Camden Lo, Zhe Hao Tan, Songhui Li, Susan K. Nilsson, A. Richard Kitching, Michael J. Hickey
Format: Article
Language:English
Published: Nature Portfolio 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03181-4

Internet

https://doi.org/10.1038/s41467-018-03181-4

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