Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes
Monocytes constitutively adhere and crawl along the glomerular endothelium and are thought to contribute to glomerulonephritis. Here the authors use multiphoton microscopy to show local antigen presentation by MHCII+ monocytes to T cells in glomerular capillaries of mice.
Bibliographic Details
| Main Authors: |
Clare L. V. Westhorpe,
M. Ursula Norman,
Pam Hall,
Sarah L. Snelgrove,
Michaela Finsterbusch,
Anqi Li,
Camden Lo,
Zhe Hao Tan,
Songhui Li,
Susan K. Nilsson,
A. Richard Kitching,
Michael J. Hickey |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2018-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-03181-4
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