Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes
Monocytes constitutively adhere and crawl along the glomerular endothelium and are thought to contribute to glomerulonephritis. Here the authors use multiphoton microscopy to show local antigen presentation by MHCII+ monocytes to T cells in glomerular capillaries of mice.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03181-4 |
| _version_ | 1830177571364405248 |
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| author | Clare L. V. Westhorpe M. Ursula Norman Pam Hall Sarah L. Snelgrove Michaela Finsterbusch Anqi Li Camden Lo Zhe Hao Tan Songhui Li Susan K. Nilsson A. Richard Kitching Michael J. Hickey |
| author_facet | Clare L. V. Westhorpe M. Ursula Norman Pam Hall Sarah L. Snelgrove Michaela Finsterbusch Anqi Li Camden Lo Zhe Hao Tan Songhui Li Susan K. Nilsson A. Richard Kitching Michael J. Hickey |
| author_sort | Clare L. V. Westhorpe |
| collection | DOAJ |
| description | Monocytes constitutively adhere and crawl along the glomerular endothelium and are thought to contribute to glomerulonephritis. Here the authors use multiphoton microscopy to show local antigen presentation by MHCII+ monocytes to T cells in glomerular capillaries of mice. |
| first_indexed | 2024-12-17T19:26:30Z |
| format | Article |
| id | doaj.art-22e1efaabd3040d59c9272c8e00fd9af |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T19:26:30Z |
| publishDate | 2018-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-22e1efaabd3040d59c9272c8e00fd9af2022-12-21T21:35:21ZengNature PortfolioNature Communications2041-17232018-02-019111410.1038/s41467-018-03181-4Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytesClare L. V. Westhorpe0M. Ursula Norman1Pam Hall2Sarah L. Snelgrove3Michaela Finsterbusch4Anqi Li5Camden Lo6Zhe Hao Tan7Songhui Li8Susan K. Nilsson9A. Richard Kitching10Michael J. Hickey11Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical CentreCentre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical CentreCentre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical CentreCentre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical CentreCentre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical CentreCentre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical CentreMonash Micro Imaging, Monash UniversityCentre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical CentreBiomedical Manufacturing, CSIRO ManufacturingBiomedical Manufacturing, CSIRO ManufacturingCentre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical CentreCentre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical CentreMonocytes constitutively adhere and crawl along the glomerular endothelium and are thought to contribute to glomerulonephritis. Here the authors use multiphoton microscopy to show local antigen presentation by MHCII+ monocytes to T cells in glomerular capillaries of mice.https://doi.org/10.1038/s41467-018-03181-4 |
| spellingShingle | Clare L. V. Westhorpe M. Ursula Norman Pam Hall Sarah L. Snelgrove Michaela Finsterbusch Anqi Li Camden Lo Zhe Hao Tan Songhui Li Susan K. Nilsson A. Richard Kitching Michael J. Hickey Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes Nature Communications |
| title | Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes |
| title_full | Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes |
| title_fullStr | Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes |
| title_full_unstemmed | Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes |
| title_short | Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes |
| title_sort | effector cd4 t cells recognize intravascular antigen presented by patrolling monocytes |
| url | https://doi.org/10.1038/s41467-018-03181-4 |
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