Efficient and specific internal cleavage of a retroviral palindromic DNA sequence by tetrameric HIV-1 integrase.

Efficient and specific internal cleavage of a retroviral palindromic DNA sequence by tetrameric HIV-1 integrase.

BACKGROUND: HIV-1 integrase (IN) catalyses the retroviral integration process, removing two nucleotides from each long terminal repeat and inserting the processed viral DNA into the target DNA. It is widely assumed that the strand transfer step has no sequence specificity. However, recently, it has...

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Bibliographic Details
Main Authors: Olivier Delelis, Vincent Parissi, Hervé Leh, Gladys Mbemba, Caroline Petit, Pierre Sonigo, Eric Deprez, Jean-François Mouscadet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1905944?pdf=render

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http://europepmc.org/articles/PMC1905944?pdf=render

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