Hfe Gene Knock-Out in a Mouse Model of Hereditary Hemochromatosis Affects Bodily Iron Isotope Compositions

Hfe Gene Knock-Out in a Mouse Model of Hereditary Hemochromatosis Affects Bodily Iron Isotope Compositions

Hereditary hemochromatosis is a genetic iron overload disease related to a mutation within the HFE gene that controls the expression of hepcidin, the master regulator of systemic iron metabolism. The natural stable iron isotope composition in whole blood of control subjects is different from that of...

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Bibliographic Details
Main Authors: Emmanuelle Albalat, Thibault Cavey, Patricia Leroyer, Martine Ropert, Vincent Balter, Olivier Loréal
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Medicine
Subjects:
iron isotope
organs
mouse model
iron overloaded
hereditary hemochromatosis (HFE)
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.711822/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.711822/full

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