Activation of recombinational repair in Ewing sarcoma cells carrying EWS-FLI1 fusion gene by chromosome translocation

Activation of recombinational repair in Ewing sarcoma cells carrying EWS-FLI1 fusion gene by chromosome translocation

Abstract Chromosome translocation (TL) is an important mode of genomic changes underlying human tumorigenesis, the detailed mechanisms of which are, however, still not well understood. The two major modalities of DNA double strand break repair, i.e. homologous recombination (HR) and non-homologous e...

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Bibliographic Details
Main Authors: Kazuhiro Tanaka, Keiji Suzuki, Kaname Miyashita, Kentaro Wakasa, Masanori Kawano, Yoshimichi Nakatsu, Hiroshi Tsumura, Mitsuaki A. Yoshida, Shinya Oda
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-19164-x

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https://doi.org/10.1038/s41598-022-19164-x

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