Melatonin mitigates doxorubicin induced chemo brain in a rat model in a NRF2/p53–SIRT1 dependent pathway

Melatonin mitigates doxorubicin induced chemo brain in a rat model in a NRF2/p53–SIRT1 dependent pathway

Cancer is a critical health problem, and chemotherapy administration is mandatory for its eradication. However, chemotherapy like doxorubicin (Dox) has serious side-effects including cognitive impairment or chemo brain. Melatonin is a neuroprotective agent that has antioxidant, and anti-inflammatory...

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Bibliographic Details
Main Authors: Neven A. Ebrahim, Mohamed R. Elnagar, Randa El-Gamal, Ola Ali Habotta, Emad A. Albadawi, Muayad Albadrani, Abdulrahman S. Bahashwan, Hend M. Hassan
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Heliyon
Subjects:
Melatonin
Doxorubicin
Chemo brain
Nrf2
p53
SIRT1
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024141126

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http://www.sciencedirect.com/science/article/pii/S2405844024141126

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