Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling

Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling

Insulin and IGF-1 receptors (IR and IGF1R) are highly homologous and share similar signaling systems, but each has a unique physiological role, with IR primarily regulating metabolic homeostasis and IGF1R regulating mitogenic control and growth. Here, we show that replacement of a single amino acid...

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Bibliographic Details
Main Authors: Hirofumi Nagao, Weikang Cai, Bruna B. Brandão, Nicolai J. Wewer Albrechtsen, Martin Steger, Arijeet K. Gattu, Hui Pan, Jonathan M. Dreyfuss, F. Thomas Wunderlich, Matthias Mann, C. Ronald Kahn
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-02-01
Series:The Journal of Clinical Investigation
Subjects:
Endocrinology
Metabolism
Online Access:https://doi.org/10.1172/JCI161472

Internet

https://doi.org/10.1172/JCI161472

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