Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells

Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells

The differentiation of patient-specific induced pluripotent stem cells (iPSCs) into specific neuronal subtypes has been exploited as an approach for modeling a variety of neurological disorders. However, achieving a highly pure population of neurons is challenging when using directed differentiation...

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Bibliographic Details
Main Authors: Muwan Chen, Muyesier Maimaitili, Mette Habekost, Katherine P. Gill, Noëmie Mermet-Joret, Sadegh Nabavi, Fabia Febbraro, Mark Denham
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Stem Cell Research
Subjects:
Induced pluripotent stem cells
Direct conversion
Patterning
Cortical neurons
V2a interneuron
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120302464

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http://www.sciencedirect.com/science/article/pii/S1873506120302464

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