Preclinical evaluation of an 18F-labeled N ε-acryloyllysine piperazide for covalent targeting of transglutaminase 2

Preclinical evaluation of an 18F-labeled N ε-acryloyllysine piperazide for covalent targeting of transglutaminase 2

Abstract Background Transglutaminase 2 (TGase 2) is a multifunctional protein and has a prominent role in various (patho)physiological processes. In particular, its transamidase activity, which is rather latent under physiological conditions, gains importance in malignant cells. Thus, there is a gre...

Full description

Bibliographic Details
Main Authors: Robert Wodtke, Markus Laube, Sandra Hauser, Sebastian Meister, Friedrich-Alexander Ludwig, Steffen Fischer, Klaus Kopka, Jens Pietzsch, Reik Löser
Format: Article
Language:English
Published: SpringerOpen 2024-01-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Biodistribution
Defluorination
Drug metabolism
Fluorine-18 chemistry
PET imaging
Pharmacokinetics
Online Access:https://doi.org/10.1186/s41181-023-00231-1

Internet

https://doi.org/10.1186/s41181-023-00231-1

Similar Items