Novel Acetylcholinesterase Inhibitors Based on Uracil Moiety for Possible Treatment of Alzheimer Disease

Novel Acetylcholinesterase Inhibitors Based on Uracil Moiety for Possible Treatment of Alzheimer Disease

In this study, novel derivatives based on 6-methyluracil and condensed uracil were synthesized, namely, 2,4-quinazoline-2,4-dione with ω-(<i>ortho</i>-nitrilebenzylethylamino) alkyl chains at the N atoms of the pyrimidine ring. In this series of synthesized compounds, the polymethylene c...

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Bibliographic Details
Main Authors: Vyacheslav E. Semenov, Irina V. Zueva, Marat A. Mukhamedyarov, Sofya V. Lushchekina, Elena O. Petukhova, Lilya M. Gubaidullina, Evgeniya S. Krylova, Lilya F. Saifina, Oksana A. Lenina, Konstantin A. Petrov
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
acetylcholinesterase
6-methyluracil
inhibitors
peripheral anionic site
Alzheimer disease
Online Access:https://www.mdpi.com/1420-3049/25/18/4191

Internet

https://www.mdpi.com/1420-3049/25/18/4191

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