Mechanistic Illustration: How Newly-Formed Blood Vessels Stopped by the Mineral Blocks of Bone Substitutes Can Be Avoided by Using Innovative Combined Therapeutics

Mechanistic Illustration: How Newly-Formed Blood Vessels Stopped by the Mineral Blocks of Bone Substitutes Can Be Avoided by Using Innovative Combined Therapeutics

One major limitation for the vascularization of bone substitutes used for filling is the presence of mineral blocks. The newly-formed blood vessels are stopped or have to circumvent the mineral blocks, resulting in inefficient delivery of oxygen and nutrients to the implant. This leads to necrosis w...

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Bibliographic Details
Main Authors: Fabien Bornert, François Clauss, Guoqiang Hua, Ysia Idoux-Gillet, Laetitia Keller, Gabriel Fernandez De Grado, Damien Offner, Rana Smaida, Quentin Wagner, Florence Fioretti, Sabine Kuchler-Bopp, Georg Schulz, Wolfgang Wenzel, Luca Gentile, Laurent Risser, Bert Müller, Olivier Huck, Nadia Benkirane-Jessel
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomedicines
Subjects:
therapeutic bone filling
pro-angiogenic smart nanotechnology
hybrid bone substitute
smart nano-active complexes
Online Access:https://www.mdpi.com/2227-9059/9/8/952

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https://www.mdpi.com/2227-9059/9/8/952

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