NFAT5/TonEBP Limits Pulmonary Vascular Resistance in the Hypoxic Lung by Controlling Mitochondrial Reactive Oxygen Species Generation in Arterial Smooth Muscle Cells

NFAT5/TonEBP Limits Pulmonary Vascular Resistance in the Hypoxic Lung by Controlling Mitochondrial Reactive Oxygen Species Generation in Arterial Smooth Muscle Cells

Chronic hypoxia increases the resistance of pulmonary arteries by stimulating their contraction and augmenting their coverage by smooth muscle cells (SMCs). While these responses require adjustment of the vascular SMC transcriptome, regulatory elements are not well defined in this context. Here, we...

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Bibliographic Details
Main Authors: Hebatullah Laban, Sophia Siegmund, Maren Zappe, Felix A. Trogisch, Jörg Heineke, Carolina De La Torre, Beate Fisslthaler, Caroline Arnold, Jonathan Lauryn, Michael Büttner, Carolin Mogler, Katsuhiro Kato, Ralf H. Adams, Hanna Kuk, Andreas Fischer, Markus Hecker, Wolfgang M. Kuebler, Thomas Korff
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
pulmonary artery
smooth muscle cells
NFAT5
transcriptome
mitochondrial ROS
Online Access:https://www.mdpi.com/2073-4409/10/12/3293

Internet

https://www.mdpi.com/2073-4409/10/12/3293

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