Response Surface Methodology (RSM) Powered Formulation Development, Optimization and Evaluation of Thiolated Based Mucoadhesive Nanocrystals for Local Delivery of Simvastatin

Response Surface Methodology (RSM) Powered Formulation Development, Optimization and Evaluation of Thiolated Based Mucoadhesive Nanocrystals for Local Delivery of Simvastatin

In oral administration systems, mucoadhesive polymers are crucial for drug localization and target-specific activities. The current work focuses on the application of thiolated xanthan gum (TXG) to develop and characterize a novel mucoadhesive nanocrystal (NC) system of simvastatin (SIM). Preparatio...

Full description

Bibliographic Details
Main Authors: Rana B. Bakhaidar, Nimbagal Raghavendra Naveen, Pratap Basim, Samar S. Murshid, Mallesh Kurakula, Abdulmohsin J. Alamoudi, Deena M. Bukhary, Abdulmajeed M. Jali, Mohammed A. Majrashi, Sameer Alshehri, Mohammed Alissa, Rayan A. Ahmed
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Polymers
Subjects:
health care
simvastatin
xanthan gum
thiolation
mucoadhesion
response surface methodology
Online Access:https://www.mdpi.com/2073-4360/14/23/5184

Internet

https://www.mdpi.com/2073-4360/14/23/5184

Similar Items