DNA damage, demethylation and anticancer activity of DNA methyltransferase (DNMT) inhibitors

DNA damage, demethylation and anticancer activity of DNA methyltransferase (DNMT) inhibitors

Abstract Role of DNA damage and demethylation on anticancer activity of DNA methyltransferase inhibitors (DNMTi) remains undefined. We report the effects of DNMT1 gene deletion/disruption (DNMT1 −/− ) on anticancer activity of a class of DNMTi in vitro, in vivo and in human cancers. The gene deletio...

Full description

Bibliographic Details
Main Authors: Angelo B. A. Laranjeira, Melinda G. Hollingshead, Dat Nguyen, Robert J. Kinders, James H. Doroshow, Sherry X. Yang
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-32509-4

Internet

https://doi.org/10.1038/s41598-023-32509-4

Similar Items