Silencing Bcl-2 Expression in Epithelial Cancer Cells Using “Smart” Particles

Silencing Bcl-2 Expression in Epithelial Cancer Cells Using “Smart” Particles

Short interfering RNA (siRNA) targeted against anti-apoptotic Bcl-2 protein proved to knockdown its expression and trigger cancer cell death. We used degradable, pH-sensitive, comb-like [P(EAA-co-BMA)-b-PNASI-g-P(HMA-co-TMAEMA)] polymer to condense anti-Bcl-2 siRNA into “smart” particles, which prov...

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Bibliographic Details
Main Authors: Yen-Ling Lin, Guohua Jiang, Zhaocheng Zhang, Jacques E. Nör, Mohamed E. H. ElSayed
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:Journal of Functional Biomaterials
Subjects:
pH-sensitive comb-like polymers
smart particles
endosomal escape
cytoplasmic siRNA delivery
Bcl-2 knockdown
Online Access:http://www.mdpi.com/2079-4983/5/3/167

Internet

http://www.mdpi.com/2079-4983/5/3/167

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