Selective depletion of metastatic stem cells as therapy for human colorectal cancer

Selective depletion of metastatic stem cells as therapy for human colorectal cancer

Abstract Selective elimination of metastatic stem cells (MetSCs) promises to block metastatic dissemination. Colorectal cancer (CRC) cells overexpressing CXCR4 display trafficking functions and metastasis‐initiating capacity. We assessed the antimetastatic activity of a nanoconjugate (T22‐GFP‐H6‐FdU...

Full description

Bibliographic Details
Main Authors: María Virtudes Céspedes, Ugutz Unzueta, Anna Aviñó, Alberto Gallardo, Patricia Álamo, Rita Sala, Alejandro Sánchez‐Chardi, Isolda Casanova, María Antònia Mangues, Antonio Lopez‐Pousa, Ramón Eritja, Antonio Villaverde, Esther Vázquez, Ramón Mangues
Format: Article
Language:English
Published: Springer Nature 2018-09-01
Series:EMBO Molecular Medicine
Subjects:
colorectal cancer
CXCR4 receptor
metastatic stem cells
protein nanoconjugate
targeted drug delivery
Online Access:https://doi.org/10.15252/emmm.201708772

Internet

https://doi.org/10.15252/emmm.201708772

Similar Items