Phosphoprotein phosphatase activity positively regulates oligomeric pyrin to trigger inflammasome assembly in phagocytes

Phosphoprotein phosphatase activity positively regulates oligomeric pyrin to trigger inflammasome assembly in phagocytes

ABSTRACT Pyrin is a pattern-recognition receptor in phagocytes that triggers caspase-1 inflammasome assembly in response to bacterial toxins and effectors that inactivate RhoA. Pyrin contains oligomerization domains and is negatively regulated by phosphorylation of two residues, S205 and S241 (murin...

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Bibliographic Details
Main Authors: Haleema S. Malik, Flora Magnotti, Nicole A. Loeven, Jose M. Delgado, Arminja N. Kettenbach, Thomas Henry, James B. Bliska
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
phosphoprotein phosphatase
pyrin
inflammasome
phagocyte
Online Access:https://journals.asm.org/doi/10.1128/mbio.02066-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02066-23

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