CRISPR/Cas9 delivery by NIR-responsive biomimetic nanoparticles for targeted HBV therapy

CRISPR/Cas9 delivery by NIR-responsive biomimetic nanoparticles for targeted HBV therapy

Abstract Background Currently, there are no curative drugs for hepatitis B virus (HBV). Complete elimination of HBV covalently closed circular DNA (cccDNA) is key to the complete cure of hepatitis B virus infection. The CRISPR/Cas9 system can directly destroy HBV cccDNA. However, a CRISPR/Cas9 deliv...

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Bibliographic Details
Main Authors: Dan Wang, Ling Chen, Chengbi Li, Quanxin Long, Qing Yang, Ailong Huang, Hua Tang
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Nanobiotechnology
Subjects:
CRISPR/Cas9
UCNP
Biomimetic nanoparticles
On-demand release
HBV
Antiviral therapy
Online Access:https://doi.org/10.1186/s12951-021-01233-4

Internet

https://doi.org/10.1186/s12951-021-01233-4

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