Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions.

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions.

Lactate has long been considered a "waste" by-product of cell metabolism, and it accumulates at sites of inflammation. Recent findings have identified lactate as an active metabolite in cell signalling, although its effects on immune cells during inflammation are largely unexplored. Here w...

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Bibliographic Details
Main Authors: Robert Haas, Joanne Smith, Vidalba Rocher-Ros, Suchita Nadkarni, Trinidad Montero-Melendez, Fulvio D'Acquisto, Elliot J Bland, Michele Bombardieri, Costantino Pitzalis, Mauro Perretti, Federica M Marelli-Berg, Claudio Mauro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-07-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC4504715?pdf=render

Internet

http://europepmc.org/articles/PMC4504715?pdf=render

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