Regioselective binding of spermine, N1,N12-bismethylspermine, and N1,N12-bisethylspermine to tRNAPhe as revealed by 750 MHz 1H-NMR and its possible correlation with cell cycling and cytotoxicity

Regioselective binding of spermine, N1,N12-bismethylspermine, and N1,N12-bisethylspermine to tRNAPhe as revealed by 750 MHz 1H-NMR and its possible correlation with cell cycling and cytotoxicity

The binding of spermine (SPM), N¹,N12-bismethylspermine (BMS) and N¹,N12-bisethylspermine (BES) to tRNA Phe was studied using ¹H-NMR at 750 MHz. The polyamines were enriched in 13C at the 5-CH2 and 8-CH2 residues and the nuclear Overhauser enhancement (NOE) cross peaks connecting the ¹H-NMR resonanc...

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Bibliographic Details
Main Authors: Frydman Benjamin, Westler William M., Valasinas Aldonia, Kramer Debora L., Porter Carl W.
Format: Article
Language:English
Published: Sociedade Brasileira de Química 1999-01-01
Series:Journal of the Brazilian Chemical Society
Subjects:
¹H-NMR of polyamines
tRNA Phe
melanoma
spermine
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531999000400014

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531999000400014

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