Enhancing the prediction of protein pairings between interacting families using orthology information
<p>Abstract</p> <p>Background</p> <p>It has repeatedly been shown that interacting protein families tend to have similar phylogenetic trees. These similarities can be used to predicting the mapping between two families of interacting proteins (i.e. which proteins from o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-01-01
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| Series: | BMC Bioinformatics |
| Online Access: | http://www.biomedcentral.com/1471-2105/9/35 |
| _version_ | 1818807901602447360 |
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| author | Pazos Florencio Pons Carles Juan David Izarzugaza Jose MG Valencia Alfonso |
| author_facet | Pazos Florencio Pons Carles Juan David Izarzugaza Jose MG Valencia Alfonso |
| author_sort | Pazos Florencio |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>It has repeatedly been shown that interacting protein families tend to have similar phylogenetic trees. These similarities can be used to predicting the mapping between two families of interacting proteins (i.e. which proteins from one family interact with which members of the other). The correct mapping will be that which maximizes the similarity between the trees. The two families may eventually comprise orthologs and paralogs, if members of the two families are present in more than one organism. This fact can be exploited to restrict the possible mappings, simply by impeding links between proteins of different organisms. We present here an algorithm to predict the mapping between families of interacting proteins which is able to incorporate information regarding orthologues, or any other assignment of proteins to "classes" that may restrict possible mappings.</p> <p>Results</p> <p>For the first time in methods for predicting mappings, we have tested this new approach on a large number of interacting protein domains in order to statistically assess its performance. The method accurately predicts around 80% in the most favourable cases. We also analysed in detail the results of the method for a well defined case of interacting families, the sensor and kinase components of the Ntr-type two-component system, for which up to 98% of the pairings predicted by the method were correct.</p> <p>Conclusion</p> <p>Based on the well established relationship between tree similarity and interactions we developed a method for predicting the mapping between two interacting families using genomic information alone. The program is available through a web interface.</p> |
| first_indexed | 2024-12-18T19:33:02Z |
| format | Article |
| id | doaj.art-2310c309f0d449368ebe0470b67a8742 |
| institution | Directory Open Access Journal |
| issn | 1471-2105 |
| language | English |
| last_indexed | 2024-12-18T19:33:02Z |
| publishDate | 2008-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Bioinformatics |
| spelling | doaj.art-2310c309f0d449368ebe0470b67a87422022-12-21T20:55:41ZengBMCBMC Bioinformatics1471-21052008-01-01913510.1186/1471-2105-9-35Enhancing the prediction of protein pairings between interacting families using orthology informationPazos FlorencioPons CarlesJuan DavidIzarzugaza Jose MGValencia Alfonso<p>Abstract</p> <p>Background</p> <p>It has repeatedly been shown that interacting protein families tend to have similar phylogenetic trees. These similarities can be used to predicting the mapping between two families of interacting proteins (i.e. which proteins from one family interact with which members of the other). The correct mapping will be that which maximizes the similarity between the trees. The two families may eventually comprise orthologs and paralogs, if members of the two families are present in more than one organism. This fact can be exploited to restrict the possible mappings, simply by impeding links between proteins of different organisms. We present here an algorithm to predict the mapping between families of interacting proteins which is able to incorporate information regarding orthologues, or any other assignment of proteins to "classes" that may restrict possible mappings.</p> <p>Results</p> <p>For the first time in methods for predicting mappings, we have tested this new approach on a large number of interacting protein domains in order to statistically assess its performance. The method accurately predicts around 80% in the most favourable cases. We also analysed in detail the results of the method for a well defined case of interacting families, the sensor and kinase components of the Ntr-type two-component system, for which up to 98% of the pairings predicted by the method were correct.</p> <p>Conclusion</p> <p>Based on the well established relationship between tree similarity and interactions we developed a method for predicting the mapping between two interacting families using genomic information alone. The program is available through a web interface.</p>http://www.biomedcentral.com/1471-2105/9/35 |
| spellingShingle | Pazos Florencio Pons Carles Juan David Izarzugaza Jose MG Valencia Alfonso Enhancing the prediction of protein pairings between interacting families using orthology information BMC Bioinformatics |
| title | Enhancing the prediction of protein pairings between interacting families using orthology information |
| title_full | Enhancing the prediction of protein pairings between interacting families using orthology information |
| title_fullStr | Enhancing the prediction of protein pairings between interacting families using orthology information |
| title_full_unstemmed | Enhancing the prediction of protein pairings between interacting families using orthology information |
| title_short | Enhancing the prediction of protein pairings between interacting families using orthology information |
| title_sort | enhancing the prediction of protein pairings between interacting families using orthology information |
| url | http://www.biomedcentral.com/1471-2105/9/35 |
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