Optical Redox Imaging of Ex Vivo Hippocampal Tissue Reveals Age-Dependent Alterations in the 5XFAD Mouse Model of Alzheimer’s Disease

Optical Redox Imaging of Ex Vivo Hippocampal Tissue Reveals Age-Dependent Alterations in the 5XFAD Mouse Model of Alzheimer’s Disease

A substantial decline in nicotinamide adenine dinucleotide (NAD) has been reported in brain tissue homogenates or neurons isolated from Alzheimer’s disease (AD) models. NAD, together with flavin adenine dinucleotide (FAD), critically supports energy metabolism and maintains mitochondrial redox homeo...

Full description

Bibliographic Details
Main Authors: He N. Xu, Sarah Gourmaud, Allison Podsednik, Xiaofan Li, Huaqing Zhao, Frances E. Jensen, Delia M. Talos, Lin Z. Li
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Metabolites
Subjects:
NAD redox
FAD-containing flavoproteins
redox ratio
amyloid-β
redox shift
Online Access:https://www.mdpi.com/2218-1989/12/9/786

Internet

https://www.mdpi.com/2218-1989/12/9/786

Similar Items