Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca2+/calpain might contribute to postoperative cognitive dysfunction in aging mice

Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca2+/calpain might contribute to postoperative cognitive dysfunction in aging mice

Abstract Background Postoperative cognitive decline (POCD) is a recognized clinical phenomenon characterized by cognitive impairments in patients following anesthesia and surgery, yet its underlying mechanism remains unclear. Brain-derived neurotrophic factor (BDNF) plays an important role in neuron...

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Bibliographic Details
Main Authors: Li-Li Qiu, Wei Pan, Dan Luo, Guang-Fen Zhang, Zhi-Qiang Zhou, Xiao-Yun Sun, Jian-Jun Yang, Mu-Huo Ji
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Neuroinflammation
Subjects:
Surgery
Cognitive dysfunction
Neuroinflammatioin
NMDAR
Calpain
BDNF
Online Access:https://doi.org/10.1186/s12974-019-1695-x

Internet

https://doi.org/10.1186/s12974-019-1695-x

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