IL-15 boosts activated HBV core-specific CD8+ progenitor cells via metabolic rebalancing in persistent HBV infection

IL-15 boosts activated HBV core-specific CD8+ progenitor cells via metabolic rebalancing in persistent HBV infection

Summary: A rebalance between energy supply and demand in HBV-specific-CD8+ activated progenitor (AP) cells could restore the functionality of proliferative progeny (PP) in e-antigen(Ag)-negative chronic hepatitis B (CHBe(−)). We observed that quiescent progenitor (QP [TCF1+/FSClow]) HBVcore-specific...

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Bibliographic Details
Main Authors: Julia Peña-Asensio, Henar Calvo-Sánchez, Joaquín Miquel, Eduardo Sanz-de-Villalobos, Alejandro González-Praetorius, Miguel Torralba, Juan-Ramón Larrubia
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:iScience
Subjects:
Biological sciences
Microbiology
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223027438

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http://www.sciencedirect.com/science/article/pii/S2589004223027438

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