The polyol pathway and nuclear ketohexokinase A signaling drive hyperglycemia-induced metastasis of gastric cancer

Abstract Diabetes might be associated with increased cancer risk, with several studies reporting hyperglycemia as a primary oncogenic stimulant. Since glucose metabolism is linked to numerous metabolic pathways, it is difficult to specify the mechanisms underlying hyperglycemia-induced cancer progre...

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Bibliographic Details
Main Authors: Ye-Lim Kang, Jiyoung Kim, Su-Bin Kwak, Yi-Sook Kim, June Huh, Jong-Wan Park
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-023-01153-3