NAIP/NLRC4 inflammasome participates in macrophage responses to Trypanosoma cruzi by a mechanism that relies on cathepsin-dependent caspase-1 cleavage

NAIP/NLRC4 inflammasome participates in macrophage responses to Trypanosoma cruzi by a mechanism that relies on cathepsin-dependent caspase-1 cleavage

Inflammasomes are large protein complexes that, once activated, initiate inflammatory responses by activating the caspase-1 protease. They play pivotal roles in host defense against pathogens. The well-established role of NAIP/NLRC4 inflammasome in bacterial infections involves NAIP proteins functio...

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Bibliographic Details
Main Authors: Marcelo Pires Amaral, Felipe Daniel Cardoso, Ingrid Sancho de Farias, Rafael Queiroz de Souza, Kely Catarine Matteucci, Ana Claudia Torrecilhas, Karina Ramalho Bortoluci
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
NAIP/NLRC4
inflammasome
Trypanosoma cruzi
cathepsins
caspase-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1282856/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1282856/full

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