Treatment of rheumatoid arthritis with dissymmetric fluorine and pyridyl-substituted 3,5-bis(aryl)-4-piperidone derivatives by inhibition of NF-κB and MAPK activation

Treatment of rheumatoid arthritis with dissymmetric fluorine and pyridyl-substituted 3,5-bis(aryl)-4-piperidone derivatives by inhibition of NF-κB and MAPK activation

Inhibition of inflammation-related NF-κB and MAPK activation could treat rheumatoid arthritis (RA). Previously, some fluorine-substituted 3,5-bis(aryl)-4-piperidone derivatives (BAPs) exhibited promising anti-inflammatory activity. Herein, interesting structural optimization was carried out and gene...

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Bibliographic Details
Main Authors: Wei-Bin Yan, Wen-Xuan Li, Yue Zhang, Lu Yu, Yu-Lun Li, Yong-Jun Liu, Gui-Ge Hou, Qing-Guo Meng, Li-Ying Ma, Zi-Kai Geng
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Arabian Journal of Chemistry
Subjects:
Rheumatoid arthritis (RA)
3,5-Bis(arylidene)-4-piperidone derivatives (BAPs)
Anti-inflammation
NF-κB
MAPK
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223009905

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http://www.sciencedirect.com/science/article/pii/S1878535223009905

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