Protease-resistant prions selectively decrease Shadoo protein.

Protease-resistant prions selectively decrease Shadoo protein.

The central event in prion diseases is the conformational conversion of the cellular prion protein (PrP(C)) into PrP(Sc), a partially protease-resistant and infectious conformer. However, the mechanism by which PrP(Sc) causes neuronal dysfunction remains poorly understood. Levels of Shadoo (Sho), a...

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Bibliographic Details
Main Authors: Joel C Watts, Jan Stöhr, Sumita Bhardwaj, Holger Wille, Abby Oehler, Stephen J Dearmond, Kurt Giles, Stanley B Prusiner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-11-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3219722?pdf=render

Internet

http://europepmc.org/articles/PMC3219722?pdf=render

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