Delineation of G Protein-Coupled Receptor Kinase Phosphorylation Sites within the D<sub>1</sub> Dopamine Receptor and Their Roles in Modulating β-Arrestin Binding and Activation

Delineation of G Protein-Coupled Receptor Kinase Phosphorylation Sites within the D<sub>1</sub> Dopamine Receptor and Their Roles in Modulating β-Arrestin Binding and Activation

The D<sub>1</sub> dopamine receptor (D1R) is a G protein-coupled receptor that signals through activating adenylyl cyclase and raising intracellular cAMP levels. When activated, the D1R also recruits the scaffolding protein β-arrestin, which promotes receptor desensitization and internal...

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Bibliographic Details
Main Authors: Amy E. Moritz, Nora S. Madaras, Michele L. Rankin, Laura R. Inbody, David R. Sibley
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
dopamine
D<sub>1</sub> receptor
phosphorylation
β-arrestin
Online Access:https://www.mdpi.com/1422-0067/24/7/6599

Internet

https://www.mdpi.com/1422-0067/24/7/6599

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