SCEPTRE improves calibration and sensitivity in single-cell CRISPR screen analysis
Abstract Single-cell CRISPR screens are a promising biotechnology for mapping regulatory elements to target genes at genome-wide scale. However, technical factors like sequencing depth impact not only expression measurement but also perturbation detection, creating a confounding effect. We demonstra...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-12-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-021-02545-2 |