The making of multivalent gamma delta TCR anti-CD3 bispecific T cell engagers

The making of multivalent gamma delta TCR anti-CD3 bispecific T cell engagers

IntroductionWe have recently developed a novel T cell engager concept by utilizing γ9δ2TCR as tumor targeting domain, named gamma delta TCR anti-CD3 bispecific molecule (GAB), targeting the phosphoantigen-dependent orchestration of BTN2A1 and BTN3A1 at the surface of cancer cells. GABs are made by...

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Bibliographic Details
Main Authors: Eline van Diest, Mara J. T. Nicolasen, Lovro Kramer, Jiali Zheng, Patricia Hernández-López, Dennis X. Beringer, Jürgen Kuball
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
tumor immunology
bispecific T cell engager
gamma delta TCR
protein engineering
Gamma Delta T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1052090/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1052090/full

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