The making of multivalent gamma delta TCR anti-CD3 bispecific T cell engagers

The making of multivalent gamma delta TCR anti-CD3 bispecific T cell engagers

IntroductionWe have recently developed a novel T cell engager concept by utilizing γ9δ2TCR as tumor targeting domain, named gamma delta TCR anti-CD3 bispecific molecule (GAB), targeting the phosphoantigen-dependent orchestration of BTN2A1 and BTN3A1 at the surface of cancer cells. GABs are made by...

Full description

Bibliographic Details
Main Authors:	Eline van Diest, Mara J. T. Nicolasen, Lovro Kramer, Jiali Zheng, Patricia Hernández-López, Dennis X. Beringer, Jürgen Kuball
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Series:	Frontiers in Immunology
Subjects:	tumor immunology bispecific T cell engager gamma delta TCR protein engineering Gamma Delta T cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1052090/full

Similar Items

Natural Self-Ligand Gamma Delta T Cell Receptors (γδTCRs) Insight: The Potential of Induced IgG
by: Thamires Rodrigues de Sousa, et al.
Published: (2020-08-01)

Enhancing the effectiveness of γδ T cells by mRNA transfection of chimeric antigen receptors or bispecific T cell engagers
by: Scott A. Becker, et al.
Published: (2023-06-01)

Human gamma delta T regulatory cells in cancer: fact or fiction?
by: Daniela eWesch, et al.
Published: (2014-11-01)

Silent T-cell receptor cutaneous T-cell lymphoma associated to a clonal plasma cell proliferation
by: Ana Caballero, et al.
Published: (2019-02-01)

Editorial: Next generation γδ T cell-based tumor immunotherapy
by: Andy Hee-Meng Tan, et al.
Published: (2022-09-01)

Clinical, Diagnostic and Prognostic Characteristics of Primary Cutaneous Gamma Delta T-cell Lymphomas
by: Ibrahim N. Muhsen, et al.
Published: (2022-06-01)

Gamma delta T cells recognize haptens and mount a hapten-specific response
by: Xun Zeng, et al.
Published: (2014-09-01)

Isolated bone marrow gamma-delta T-Cell lymphoma: Another challenge to the WHO lymphoid neoplasm classification
by: Rohit Singh, et al.
Published: (2023-01-01)

Human peripheral CD4+ Vdelta1+ gamma delta T cells can develop into alpha beta T cells
by: Hendrik eZiegler, et al.
Published: (2014-12-01)

Primary Cutaneous Gamma-Delta T-cell Lymphoma: Not an Aggressive Disease in All Cases
by: Mehdi Khallaayoune, et al.
Published: (2020-01-01)

Molecular mechanisms of differentiation of murine pro-inflammatory gamma-delta T cell subsets
by: Bruno eSilva-Santos, et al.
Published: (2013-12-01)

Contemplating Dichotomous Nature of Gamma Delta T Cells for Immunotherapy
by: Jaydeep Bhat, et al.
Published: (2022-05-01)

The emerging roles of gamma-delta T cells in tissue inflammation in experimental autoimmune encephalomyelitis
by: Amit eAwasthi, et al.
Published: (2016-01-01)

Multiple receptor-ligand interactions direct tissue resident gamma delta T cell activation
by: Deborah A. Witherden, et al.
Published: (2014-11-01)

Gamma Delta T Cells and Their Involvement in COVID-19 Virus Infections
by: Georg von Massow, et al.
Published: (2021-10-01)

Apoptosis Induced via Gamma Delta T Cell Antigen Receptor “Blocking” Antibodies: A Cautionary Tale
by: Indrani Dutta, et al.
Published: (2017-06-01)

Gamma Delta T-Cell Based Cancer Immunotherapy: Past-Present-Future
by: José Saura-Esteller, et al.
Published: (2022-06-01)

Allogeneic gamma delta T cells as adoptive cellular therapy for hematologic malignancies
by: Navdeep Jhita, et al.
Published: (2022-06-01)

Primary Cutaneous Gamma-Delta T Cell Lymphomas: A Case Series and Overview of the Literature
by: Silvia Alberti-Violetti, et al.
Published: (2021-11-01)

Mammalian Display Platform for the Maturation of Bispecific TCR-Based Molecules
by: Janine Dilchert, et al.
Published: (2022-05-01)

Unmasking a T cell lymphoma: Folliculotropic mycosis fungoides with a gamma-delta phenotype
by: Jessica Tran, BBA, et al.
Published: (2020-12-01)

Regulatory Interactions Between Neutrophils, Tumor Cells and T Cells
by: Hans-Heinrich Oberg, et al.
Published: (2019-07-01)

Monitoring circulating gammadelta T cells in cancer patients to optimize gammadelta T cell-based immunotherapy
by: Hans-Heinrich eOberg, et al.
Published: (2014-12-01)

Repertoire analysis of γδ T cells in the chicken enables functional annotation of the genomic region revealing highly variable pan-tissue TCR gamma V gene usage as well as identifying public and private repertoires
by: Robert Dixon, et al.
Published: (2021-10-01)

Phosphoantigen presentation to TCR γδ cells, a conundrum getting less grey zones
by: Gennaro eDe Libero, et al.
Published: (2015-01-01)

Recent advances in gamma/delta T cell biology: new ligands, new functions, and new translational perspectives
by: Dieter eKabelitz, et al.
Published: (2015-07-01)

Velocity anisotropy and trend in Niger Delta, Nigeria
by: Emmanuel Aniwetalu, et al.
Published: (2021-03-01)

Hepatosplenic gamma-delta T-cell lymphoma in a female patient after delivery
by: Marjana Glaser, et al.
Published: (2012-02-01)

Depletion of neutrophils in a protective model of pulmonary cryptococcosis results in increased IL-17A production by gamma/delta T cells
by: Wozniak Karen L, et al.
Published: (2012-12-01)

Gamma delta T-cell reconstitution after allogeneic HCT: A platform for cell therapy
by: Ahmed Gaballa, et al.
Published: (2022-08-01)

What Can Gamma Delta T Cells Contribute to an HIV Cure?
by: Jennifer A. Juno, et al.
Published: (2020-05-01)

Plasticity of gamma delta T cells: impact on the anti-tumor response
by: Virginie eLafont, et al.
Published: (2014-12-01)

Hepatosplenic Gamma Delta T-Cell Lymphoma (HSGDTCL): Two Rare Case Reports from Western India
by: Irappa Madabhavi, et al.
Published: (2017-10-01)

Interleukin-15 enhances the proliferation, stimulatory phenotype, and antitumor effector functions of human gamma delta T cells
by: Heleen H. Van Acker, et al.
Published: (2016-09-01)

Association between Serum Heat Shock Proteins and Gamma-Delta T Cells—An Outdated Clue or a New Direction in Searching for an Anticancer Strategy? A Short Report
by: Dorota Pawlik-Gwozdecka, et al.
Published: (2021-08-01)

Perforins Expression by Cutaneous Gamma Delta T Cells
by: Katelyn O'Neill, et al.
Published: (2020-08-01)

γδ T cells in HIV Disease: Past, Present and Future
by: C. David ePauza, et al.
Published: (2015-01-01)

Deep characterization of human γδ T cell subsets defines shared and lineage-specific traits
by: Marta Sanz, et al.
Published: (2023-03-01)

Primary Cutaneous Gamma-Delta T-Cell Lymphoma Initially Diagnosed as Subcutaneous Panniculitis-like T-Cell Lymphoma with Dermatomyositis
by: Chika Hirata, et al.
Published: (2022-04-01)

Gamma-Delta CAR-T Cells Show CAR-Directed and Independent Activity Against Leukemia
by: Meir Rozenbaum, et al.
Published: (2020-07-01)