Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications

Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications

Post-translational modifications (PTMs) to the tails of the core histone proteins are critically involved in epigenetic regulation. Hypoxia affects histone modifications by altering the activities of histone-modifying enzymes and the levels of hypoxia-inducible factor (HIF) isoforms. Synthetic hypox...

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Bibliographic Details
Main Authors: Kuo-Feng Hsu, Sarah E. Wilkins, Richard J. Hopkinson, Rok Sekirnik, Emily Flashman, Akane Kawamura, James S.O. McCullagh, Louise J. Walport, Christopher J. Schofield
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Epigenetics
Subjects:
hypoxia
histone post-translational modifications
epigenetics
hypoxia mimetics
hif
intact protein mass spectrometry
iron chelating drugs
2-oxoglutarate/α-ketoglutarate oxygenases
Online Access:http://dx.doi.org/10.1080/15592294.2020.1786305

Internet

http://dx.doi.org/10.1080/15592294.2020.1786305

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