Disjoint combinations profiling (DCP): a new method for the prediction of antibody CDR conformation from sequence

The accurate prediction of the conformation of Complementarity-Determining Regions (CDRs) is important in modelling antibodies for protein engineering applications. Specifically, the Canonical paradigm has proved successful in predicting the CDR conformation in antibody variable regions. It relies o...

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Bibliographic Details
Main Authors: Dimitris Nikoloudis, Jim E. Pitts, José W. Saldanha
Format: Article
Language:English
Published: PeerJ Inc. 2014-07-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/455.pdf