Impaired Antiviral Responses to Extracellular Double-Stranded RNA and Cytosolic DNA, but Not to Interferon-α Stimulation, in TRIM56-Deficient Cells

Impaired Antiviral Responses to Extracellular Double-Stranded RNA and Cytosolic DNA, but Not to Interferon-α Stimulation, in TRIM56-Deficient Cells

The physiologic function of tripartite motif protein 56 (TRIM56), a ubiquitously expressed E3 ligase classified within the large TRIM protein family, remains elusive. Gene knockdown studies have suggested TRIM56 as a positive regulator of the type I interferon (IFN-I) antiviral response elicited via...

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Bibliographic Details
Main Authors: Dang Wang, Ruixue Wang, Kui Li
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Viruses
Subjects:
TRIM56
interferon
interferon-stimulated gene
ISGylation
toll-like receptor 3
double-stranded RNA
Online Access:https://www.mdpi.com/1999-4915/14/1/89

Internet

https://www.mdpi.com/1999-4915/14/1/89

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