The endoribonuclease Arlr is required to maintain lipid homeostasis by downregulating lipolytic genes during aging

Abstract While disorders in lipid metabolism have been associated with aging and age-related diseases, how lipid metabolism is regulated during aging is poorly understood. Here, we characterize the Drosophila endoribonuclease CG2145, an ortholog of mammalian EndoU that we named Age-related lipid reg...

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Bibliographic Details
Main Authors: Xiaowei Sun, Jie Shen, Norbert Perrimon, Xue Kong, Dan Wang
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42042-7