The T-Type Calcium Channel Cav3.2 in Somatostatin Interneurons in Spinal Dorsal Horn Participates in Mechanosensation and Mechanical Allodynia in Mice

The T-Type Calcium Channel Cav3.2 in Somatostatin Interneurons in Spinal Dorsal Horn Participates in Mechanosensation and Mechanical Allodynia in Mice

Somatostatin-positive (SOM+) neurons have been proposed as one of the key populations of excitatory interneurons in the spinal dorsal horn involved in mechanical pain. However, the molecular mechanism for their role in pain modulation remains unknown. Here, we showed that the T-type calcium channel...

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Bibliographic Details
Main Authors: Yu-Ru Zhi, Feng Cao, Xiao-Jing Su, Shu-Wen Gao, Hao-Nan Zheng, Jin-Yan Jiang, Li Su, Jiao Liu, Yun Wang, Yan Zhang, Ying Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
intraspinal injection
knockdown
low-voltage activated calcium channel
SOM neurons
spinal cord slice recording
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.875726/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.875726/full

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