Super-Resolution Imaging of Fas/CD95 Reorganization Induced by Membrane-Bound Fas Ligand Reveals Nanoscale Clustering Upstream of FADD Recruitment

Super-Resolution Imaging of Fas/CD95 Reorganization Induced by Membrane-Bound Fas Ligand Reveals Nanoscale Clustering Upstream of FADD Recruitment

Signaling through the TNF-family receptor Fas/CD95 can trigger apoptosis or non-apoptotic cellular responses and is essential for protection from autoimmunity. Receptor clustering has been observed following interaction with Fas ligand (FasL), but the stoichiometry of Fas, particularly when triggere...

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Bibliographic Details
Main Authors: Nicholas Frazzette, Anthony C. Cruz, Xufeng Wu, John A. Hammer, Jennifer Lippincott-Schwartz, Richard M. Siegel, Prabuddha Sengupta
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
Fas
CD95
PALM imaging
super-resolution microscopy
receptor signaling
TNFR superfamily
Online Access:https://www.mdpi.com/2073-4409/11/12/1908

Internet

https://www.mdpi.com/2073-4409/11/12/1908

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