Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2

Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2

Here, Israeli and Finkel et al. perform genome-wide CRISPR knockout screens to identify host factors required for the infection with SARS-CoV-2 and two additionally variants of concern, Alpha and Beta, unveiling shared and differential host pathways required by the variants, and demonstrate GATA6 is...

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Bibliographic Details
Main Authors: Ma’ayan Israeli, Yaara Finkel, Yfat Yahalom-Ronen, Nir Paran, Theodor Chitlaru, Ofir Israeli, Inbar Cohen-Gihon, Moshe Aftalion, Reut Falach, Shahar Rotem, Uri Elia, Ital Nemet, Limor Kliker, Michal Mandelboim, Adi Beth-Din, Tomer Israely, Ofer Cohen, Noam Stern-Ginossar, Adi Bercovich-Kinori
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29896-z

Internet

https://doi.org/10.1038/s41467-022-29896-z

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