KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition

KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition

Summary: Metabolic reprogramming in cancer cells can create metabolic liabilities. KEAP1-mutant lung cancer is refractory to most current therapies. Here we show that KEAP1 deficiency promotes glucose dependency in lung cancer cells, and KEAP1-mutant/deficient lung cancer cells are more vulnerable t...

Full description

Bibliographic Details
Main Authors: Pranavi Koppula, Kellen Olszewski, Yilei Zhang, Lavanya Kondiparthi, Xiaoguang Liu, Guang Lei, Molina Das, Bingliang Fang, Masha V. Poyurovsky, Boyi Gan
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:iScience
Subjects:
physiology
cell biology
cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221006179

Internet

http://www.sciencedirect.com/science/article/pii/S2589004221006179

Similar Items