Therapeutic targeting of tumor growth and angiogenesis with a novel anti-S100A4 monoclonal antibody.

Therapeutic targeting of tumor growth and angiogenesis with a novel anti-S100A4 monoclonal antibody.

S100A4, a member of the S100 calcium-binding protein family secreted by tumor and stromal cells, supports tumorigenesis by stimulating angiogenesis. We demonstrated that S100A4 synergizes with vascular endothelial growth factor (VEGF), via the RAGE receptor, in promoting endothelial cell migration b...

Full description

Bibliographic Details
Main Authors: Jose Luis Hernández, Laura Padilla, Sheila Dakhel, Toni Coll, Rosa Hervas, Jaume Adan, Marc Masa, Francesc Mitjans, Josep Maria Martinez, Silvia Coma, Laura Rodríguez, Véronique Noé, Carlos J Ciudad, Francesc Blasco, Ramon Messeguer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3762817?pdf=render

Internet

http://europepmc.org/articles/PMC3762817?pdf=render

Similar Items