Synthesis and evaluation of a rociletinib analog as prospective imaging double mutation L858R/T790M in non-small cell lung cancer

Synthesis and evaluation of a rociletinib analog as prospective imaging double mutation L858R/T790M in non-small cell lung cancer

Context: Imaging the mutation status of non-small cell lung cancer (NSCLC) using radiolabeled tyrosine kinase inhibitor (TKI) analogs has garnered interest due to their unique interactions with the target epidermal growth factor receptor (EGFR). Rociletinib is a third-generation TKI that selectively...

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Bibliographic Details
Main Authors: Muammar Fawwaz, Kenji Mishiro, Bambang Purwono, Ryuichi Nishii, Kazuma Ogawa
Format: Article
Language:English
Published: GarVal Editorial Ltda. 2024-03-01
Series:Journal of Pharmacy & Pharmacognosy Research
Subjects:
acrylamide
carcinoma
epidermal growth factor
molecular docking simulation
mutation
Online Access:https://jppres.com/jppres/pdf/vol12/jppres23.1743_12.2.231.pdf

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https://jppres.com/jppres/pdf/vol12/jppres23.1743_12.2.231.pdf

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