PPARδ agonist protects against osteoarthritis by activating AKT/mTOR signaling pathway-mediated autophagy

PPARδ agonist protects against osteoarthritis by activating AKT/mTOR signaling pathway-mediated autophagy

Osteoarthritis (OA) is the most prevalent degenerative joint disease, and PPARs are involved in its pathogenesis; however, the specific mechanisms by which changes in PPARδ impact the OA pathogenesis yet to be discovered. The purpose of this study was to ascertain how PPARδ affects the onset and dev...

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Bibliographic Details
Main Authors: Guantong Sun, Xiaodong Li, Pengcheng Liu, Yao Wang, Cheng Yang, Shuhong Zhang, Lei Wang, Xiaoqing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
PPARδ
osteoarthritis
autophagy
apoptosis
AKT/mTOR signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1336282/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1336282/full

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