Honokiol from Magnolia spp. induces G1 arrest via disruption of EGFR stability through repressing HDAC6 deacetylated Hsp90 function in lung cancer cells

Honokiol from Magnolia spp. induces G1 arrest via disruption of EGFR stability through repressing HDAC6 deacetylated Hsp90 function in lung cancer cells

Honokiol, an active compound derived from Magnolia spp. bark, possesses chemopreventive properties in many cancer cell models. However, the chemopreventive mechanism of honokiol in lung cancer cells is still a mystery. We examined histone deacetylase 6 (HDAC6)-mediated epidermal growth factor recept...

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Bibliographic Details
Main Authors: Shiuan-Fu Liou, Kuo-Tai Hua, Chia-Yun Hsu, Meng-Shih Weng
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Journal of Functional Foods
Subjects:
Honokiol
Epidermal growth factor receptor (EGFR)
Histone deacetylase 6 (HDAC6)
Heat-shock protein 90 (Hsp90)
Hyper-acetylation
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464615001267

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http://www.sciencedirect.com/science/article/pii/S1756464615001267

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